physician photo

Jun Guo, PhD

  • Research Assistant Professor of Surgery

Medical School

 

Graduate School

Ph.D., Neurobiology, Shanghai Medical University, Shanghai, P. R. China, 2000.

Research Interests

Research associate with Dr. Brad Warner, the leading authority in the field of intestinal adaptation following massive small bowel resection.

One of focuses has been generating an in vitro cell culture system to mimic the condition in vivo to understand the signal transduction pathway of EGFR, and further to determine the mechanism for enhanced intestinal adaptation by EGF/EGFR axis stimulation.

Selected Publications

Leinicke JA, Longshore S, Wakeman D, Guo J, Warner BW. Regulation of Retinoblastoma Protein (Rb) by p21 Is Critical for Adaptation to Massive Small Bowel Resection. J Gastrointest Surg. 2012 Jan;16(1):148-55.

Wakeman D, Longshore SW, McMellen ME, Santos JA, Guo J, Erwin CR, Warner BW. Extent of small bowel resection does not influence the magnitude of intestinal adaptation in the mouse. J Pediatr Surg. 2010 Jun;45(6):1274-9.

McMellen ME, Wakeman D, Erwin CR, Guo J, Warner BW. Epidermal growth factor receptor signaling modulates chemokine (CXC) ligand 5 expression and is associated with villus angiogenesis after small bowel resection. Surgery. 2010 Aug;148(2):364-70.

Martin CA, Perrone EE, Longshore SW, Toste P, Bitter K, Nair R, Guo J, Erwin CR, Warner BW. Intestinal resection induces angiogenesis within adapting intestinal villi. J Pediatr Surg. 2009 Jun;44(6):1077-82; discussion 1083.

Longshore SW, Nair R, Perrone EE, Erwin CR, Guo J, Warner BW. p21(waf1/cip1) deficiency does not perturb the intestinal crypt stem cell population after massive small bowel resection. J Pediatr Surg. 2009 Jun;44(6):1065-71; discussion 1071.

Guo J, Longshore S, Nair R, Warner BW. Retinoblastoma protein (pRb), but not p107 or p130, is required for maintenance of enterocyte quiescence and differentiation in small intestine. J Biol Chem. 2009 Jan 2;284(1):134-40.

Taylor JA, Martin CA, Nair R, Guo J, Erwin CR, Warner BW. Lessons learned: optimization of a murine small bowel resection model. J Pediatr Surg. 2008 Jun;43(6):1018-24.

Martin CA, Bernabe KQ, Taylor JA, Nair R, Paul RJ, Guo J, Erwin CR, Warner BW. Resection-induced intestinal adaptation and the role of enteric smooth muscle. J Pediatr Surg. 2008 Jun;43(6):1011-7.

Sheng G, Guo J, Warner BW. Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G599-606. Epub 2007 Jul 5.

Taylor JA, Bernabe KQ, Guo J, Warner BW. Epidermal growth factor receptor-directed enterocyte proliferation does not induce Wnt pathway transcription. J Pediatr Surg. 2007 Jun;42(6):981-6.

Sheng G, Bernabe KQ, Guo J, Warner BW. Epidermal growth factor receptor-mediated proliferation of enterocytes requires p21waf1/cip1 expression. Gastroenterology. 2006;131(1):153-164.

Guo J, Sheng G, Warner BW. Epidermal growth factor-induced rapid retinoblastoma phosphorylation at Ser780 and Ser795 is mediated by ERK1/2 in small intestine epithelial cells. Journal of Biological Chemistry. 2005;280(43):35992-35998. Epub 2005 Aug 26

Stehr W, Bernal NP, Erwin CR, Bernabe KQ, Guo J, Warner BW. Roles for p21waf1/cip1 and p27kip1 during the adaptation response to massive intestinal resection. Am J Physiol Gastrointest Liver Physiol. 2006;290(5):G933-G941.

Salazar G, Craige B, Wainer BH, Guo J, De Camilli P, Faundez V. Phosphatidylinositol-4-Kinase Type II Alpha is a component of AP-3-derived vesicles. Molecular Biology of the Cell. 2005;16(8):3692-3704.

Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, Jahkel M, De Camilli P, Moser T, Rasband MN, Solimena M. BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments. Journal of Cell Biology. 2004;166(7):983-990.